|
|Section2= }} α-Eleostearic acid or (9''Z'',11''E'',13''E'')-octadeca-9,11,13-trienoic acid, is an organic compound, a conjugated fatty acid and one of the isomers of octadecatrienoic acid. It is often called simply eleostearic acid although there is also a β-eleostearic acid (the all-''trans'' or (9''E'',11''E'',13''E'') isomer). Its high degree of unsaturation gives tung oil its properties as a drying oil. ==Biochemical properties== In their pioneering work on essential fatty acids, Burr, Burr and Miller compared the nutritional properties of α-eleostearic acid (ELA) to that of its isomer alpha-linolenic acid (ALA). ALA relieved essential fatty acid deficiency; ELA did not.〔 In rats, α-eleostearic acid is converted to a conjugated linoleic acid.〔 〕 The compound has been found to induce programmed cell death of fat cells,〔 〕 and of HL60 leukemia cells in vitro at a concentration of 20 μM.〔Masuko Kobori, Mayumi Ohnishi-Kameyama, Yukari Akimoto, Chizuko Yukizaki and Mitsuru Yoshida (2008) ''α-Eleostearic Acid and Its Dihydroxy Derivative Are Major Apoptosis-Inducing Components of Bitter Gourd''. Journal of Agricultural and Food Chemistry, volume 56, issue 22, pages 10515–10520. 〕 Diets containing 0.01% bitter gourd seed oil (0.006% as α-eleostearic acid) were found to prevent azoxymethane-induced colon carcinogenesis in rats.〔H. Kohno, Y. Yasui, R. Suzuki, M. Hosokawa, K. Miyashita, T. Tanaka (2004), ''Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPAR γ expression and alteration of lipid composition.'' International Journal of Cancer, volume 110, pages 896–901.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Alpha-Eleostearic acid」の詳細全文を読む スポンサード リンク
|